Staffan Strömblad

 

Address: Karolinska Institutet, Dept of Biosciences and Nutrition, 141 57 Huddinge

A. Professional preparation

1988 B.Sc. Biochemistry & Microbiology, University of Stockholm.
1992 Ph.D. Karolinska Institutet. Area: Experimental Pathology. Thesis entitled: “The epidermal growth factor receptor system in rat liver growth and carcinogenesis”.
1994-1996 Post-doctoral training, The Scripps Research Institute, La Jolla, CA, in the laboratory of Dr. David A. Cheresh. Area: Integrins and angiogenesis.

B. Appointments

2003-2009

Senior scientist position (6 years) by the Swedish Research Council.

2000 Associate professor (docent), Karolinska Institutet.
1997

Principal investigator and Assistant professor, Karolinska Institutet.

1997-2003 Cancer researcher position by The Swedish Cancer Society.
1994-1996 Research associate, The Scripps Research Institute (3 yrs).
1993 Post-doctoral researcher, Karolinska Institutet.
1988-1992 Post-graduate student, Karolinska Institutet.

C. Graduated students and post-doctoral fellows

Wenjie Bao, PhD 2005-06-17; Annica Gad, PhD 2005-08-26. Totally eleven different post-doctoral fellows have worked under my supervision 1998-2006. I am presently main supervisor for 3 PhD students, and co-supervisor of 4.

D. Fellowships and awards

2007

Erik K. Fernström’s prize for young investigators, University of Lund, Sweden

2004 Awarded the KI-Cancer strategic grant
2003 Senior scientist Award position in Clinical Molecular Biology from the Swedish Research Council

1996 The Wenner-Gren Foundation post-doctoral fellowship
1994-95 The Swedish Cancer Society post-doctoral fellowship

E. Commissions of trust

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Deputy chairman of evaluation committee PKB1 (study section) at the Swedish Cancer Society 2008- .

- Member of an international evaluation board for Academy of Finland; yearly evaluations 2007- .
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Member of evaluation committee PKB (study section) at the Swedish Cancer Society 2006 - .

- Board member of the KI-Cancer network 2004-2006.
- Chairman of the review committee for the Robert Lundberg memorial foundation 2002-2005.
- Member of the department/division boards during various periods, 1988-1992 and 1997-2004.
- A long number of commissions of trust within academia as a student, including as vice president of the Federation of the Student Unions of Stockholm (SSCO) 1987-88, board member of the Stockholm Student Housing Foundation (SSSB) 1987-91 and of the Stockholm Students Sports Federation 1986-91, board member of the Stockholm University Student Union 1987-88 and Chairman of the Student health care organization in Stockholm (Studenthälsan)1987-88.
- Faculty opponent at two PhD dissertations (Tallin Technical University, Estonia, 2000; Turku University, Finland, 2005) and one licenciate dissertation (Stockholm University, Sweden, 2005).
- Assignments as ad hoc reviewer for the following journals; Artheroscl. Thrombosis Vascul. Biol.; Am. J. Pathol.; Blood; Cancer Lett.; Cell; Exp. Cell Res.; FASEB J.; J. Cell Biol.; J. Cell Sci.; J. Clin. Invest.; Mol. Biol. Cell; Proc. Natl. Acad. Sci. USA; Trends Cell Biol.; Trends Mol. Med.

F. Science and society, Entrepreneurial achievements

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Co-founder of two start-up biotech companies within the Oncology field; Angitia AB and Aprea AB, both in operation.

- Author of two patent applications.

G. Impact/citations

My scientific papers have been cited a total of more than 2700 times (ISI, May, 2008).

H. International invitations and conferences

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Invited speaker at approximately fifteen international conferences/symposia, including as a Keynote speaker at the annual meeting of the Dutch working party for tumor biology, Lunteren, The Netherlands, May 6-7, 1996.

- Invited speaker at approximately twenty foreign institutes, universities, etc.
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Organizer of an international symposium on Angiogenesis at Nobel Forum, Karolinska Institutet, September 1997.

- Organizer of a Minisymposium on Fluorescent live cell imaging at Karolinska Institutet, February 2004.

I: Five selected publications

1.

Strömblad, S., Becker, J.C., Yebra, M., Brooks, P.C. & Cheresh, D.A. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin aVß3 during angiogenesis.  J. Clin. Invest. 98, 426-433 (1996).

2. Zhang, H., Li, Z., Viklund, E-K. & Strömblad, S. p21-activated kinase 4 interacts with integrin avb5 and regulates avb5-mediated cell migration. J. Cell Biol. 158, 1287-1297 (2002).
3.

Zhang, H., Berg, J., Li, Z., Wang, Y., Lång, P., Sousa, A.D., Bhaskar, A., Cheney, R.C. & Strömblad, S.  Myosin-X provides a motor-based link between integrins and the cytoskeleton. Nature Cell Biol. 6, 523-531 (2004).

4. Bao, W. & Strömblad, S. Integrin av-mediated inactivation of p53 controls a MEK-1-dependent melanoma cell survival pathway in three-dimensional collagen. J. Cell Biol. 167, 745-756. (2004).
5. Thullberg, M., Gad, A., LeGuyader, S. & Strömblad, S. Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis. Proc Natl Acad Sci USA. 104, 20338-20343 (2007).