The MetaFight project comprises seven major interrelated Work Packages (WP) organised as follows:
WP1 is designed to investigate the molecular and functional architecture of the Core Invasive Machinery, from which depends tumour cell migration and eventually invasion.
WP2 and WP3 screen for key modulators of metastasis formation in in vivo murine models, by non-invasive imaging techniques.
WP4 is related to a comprehensive proteomic analysis of expression and phosphorylation of our candidate modulators in metastasis formation.
WP1-4 feed into WP5, which builds upon and exploits knowledge generated in the first four WPs and translates it into existing pharmacological interventions to generate new candidate drugs. This will lead to patent filing and licensing strategies.
WP6 and WP7 handle dissemination and management activities.