Centro de Investigaciones Biológicas (CIB)
The Centro de Investigaciones Biológicas (CIB) is located in Madrid, at the campus of the Universidad Complutense de Madrid. The CIB belongs to the Spanish National Research Council, the main Institution for research in Spain.
Research in CIB includes Microbiology, Protein Science, Cell Biology and Development, and Cellular and Molecular Physiopathology, the department to which our laboratory belongs. Our department's main research lines include Vascular Biology, Complement Genetics, Myeloid cell Biology, T Lymphocyte Activation, Cell adhesion in the Immune System and Cancer. Our laboratory investigates the role of chemokines in tumor cell metastasis and In T lymphocyte adhesion.
Tumor cells express chemokine receptors that contribute to the homing of these cells to organs and tissues where their chemokine ligands are expressed. Our main research goal concerns the characterization of intracellular signaling required for cell invasion and metastasis promoted by chemokines. Using in vitro and in vivo approaches we investigate the role of chemokine-activated signaling molecules in the metastasis of melanoma cells. We will study the functional cross-talks between chemokine receptors, their activated signaling targets and the Core Invasive Machinery molecules established in the Metafight Consortium, to contribute to a better knowledge of the mechanisms controlling tumor cell metastasis.
List of persons involved in MetaFight
- Prof. Joaquin Teixidó - MetaFight Principal Investigator (see short CV)
- Rubén Bartolomé - Postdoctoral Research Associate
- Georgina P. Coló - Postdoctoral Research Associate
- Pablo Hernandez-Varas - Graduate student