The Max Planck Institute of Biochemistry (MPIB)
The Max Planck Institute of Biochemistry (MPIB) is one of the largest Institutes of the Max Planck Society, a non profit research organization dedicated to top level basic research. The research focus of the institute investigates the structure, function and interaction of biological macromolecules (especially proteins) at the molecular, cellular and the organismic level. The institute has a broad methodological repertoire ranging from x-ray structural analysis of proteins to their functional analysis in transgenic organisms.
The department of Molecular Medicine (headed by Reinhard Fssler) investigates the functional properties of integrin-mediated adhesion during morphogenesis and pathology such as inflammation and cancer. Kindlin-1 is an integrin-associated protein, where it plays essential roles for integrin signalling. The signalling function will be studied during cancer development and metastasis using different mouse models.
The department of proteomics and Signal Transduction (headed by Matthias Mann) applies mass spectrometry (MS)-based quantitative proteomic and phosphoproteomics technologies to study signalling pathway in cancer. In particular, the stable-isotope labeling by amino acids in cell (SILAC) will be applied in mouse to in-vivo characterize Kindlin1 and study its role in tumor development.
List of persons involved in MetaFight
- Dr. Prof. Matthias Mann - Director of Department of Proteomics and Signal transduction, MetaFight Principal Investigator (see CV)
- Dr. Tami Geiger - Postdoctoral Research
- Dr. Sara Zanivan - Postdoctoral Research